First Reformed Church is located on the corner of Main Avenue (NY Route 66) and Church Street at the east end of the hamlet of Wynantskill in the town of North Greenbush in New York State in the USA. See the red marker on the map above.

From the east: Route 66 west, or Route 150 north to Route 66 east

From the west: Route 66 east, or Route 136 east to route 150 north to route 66 east